Main content area. The mitochondrial citrate carrier in Yarrowia lipolytica: Its identification, characterization and functional significance for the production of citric acid
Key words: citrate carrier, gene expression, lipogenesis, PUFA, rat liver, SREBP-1. INTRODUCTION Citrate carrier (CiC), (also known as tricarboxylate carrier), a mitochondrial inner membrane protein catalyzes electroneutral exchange of a tricarboxylate for either another tricarboxylate, a dicarboxylate or phosphoenolpyruvate. Abstract The tricarboxylate (citrate) carrier (TCC), a protein of the mitochondrial inner membrane, is an obligatory component of the shuttle system by which mitochondrial acetyl-CoA is transported into the cytosol, where lipogenesis occurs.
Jul 18, 2014 · The citrate carrier (CiC), characteristic of animals, and the dicarboxylate–tricarboxylate carrier (DTC), characteristic of plants and protozoa, belong to the mitochondrial carrier protein family whose members are responsible for the exchange of metabolites, cofactors, and nucleotides between the cytoplasm and the mitochondrial matrix. The increase of lipogenesis and decrease of β-oxidation led to fat accumulation and fatty liver. Chronic ethanol consumption also induced increase in PRBP and decrease in α-TTP, CAIII, Cu/Zn-SOD, rhodanese, and peroxiredoxin 1, which may cause of oxidative stress.
This volume of the series Medicinal Plants of the World: Chemical Constituents, Modern and Traditional Medicinal Usescontains information on 16 plant species and follows the same format as volumes 1 and 2. Some of the plants discussed in volume 3 may be considered controversial in their classification as “medicinal.” In the Krebs cycle, acetyl-CoA is then converted into citrate (tricarboxylate) after condensation with OAA. In a good energetic state, citrate is transported into the cytosol via CiC in exchange for malate Figure 1. Schematic model of citrate carrier (CiC) and carnitine-acylcarnitine translocase sauer h, kleineke j, söling hd. on the specificity of the tricarboxylate carrier system in rat liver mitochondria. 01 de janeiro de 1973. sauer h. [connatal and acquired oesophagus stenosis in children. changes in indication for surgery and therapy (author's transl)]. sauer h, riecken eo, trojan hj, martini ga.