Notch signaling pathway is downregulated upon Jurkat T cell activation Jurkat T cells are inherently independent on exogenous glutamine for cell survival along with a high expression of Notch1 intracellular domain but upon artificial increase of glutamine consumption, Notch signaling pathway activity was found to decrease.
T cells adjust metabolic pathways during their life cycle according to their needs. TCR activation is linked to metabolic reprogramming. Cellular metabolic regulators shape T cell responses. Manipulation of metabolic pathways can critically influence T cell activation and differentiation.
The activation of cross presenting dendritic cells is dependent on stimulation by CD4+ T helper cells. The co-stimulatory molecule CD40/CD40L along with the danger presence of an exogenous antigen are catalysts for dendritic cell licensing, and thus the cross presentation and activation of naive CD8+ cytotoxic T cells. Feb 12, 2013 · Dr. John Looney reviews T cell activation contributors, T cell antigen recognition, and T cell "braking."This webcast is part of an interactive online series designed to bring you, the busy ... Aug 27, 2013 · Also, APCs can actively intake exogenous antigens by endocytosis or phagocytosis and process into fragments in order to initiate the antigen-processing pathways. After initiating the pathway, the fragments present on the membrane together with MHC class II molecules and then allow recognizing by TH cells.
Interconnections Between the Class I and Class II Pathways Cross-Presentation: Transferring Exogenous Antigens to the Class I Pathway. Cross-presentation is the transferring of extracellular antigens like bacteria, some tumor antigens, and antigens in cells infected by viruses into the class I pathway for stimulation of CD8 + cytotoxic T cells (CTL). The activation of cross presenting dendritic cells is dependent on stimulation by CD4+ T helper cells. The co-stimulatory molecule CD40/CD40L along with the danger presence of an exogenous antigen are catalysts for dendritic cell licensing, and thus the cross presentation and activation of naive CD8+ cytotoxic T cells. Potential Function of Exogenous Vimentin on the Activation of Wnt Signaling Pathway in Cancer Cells . Arun Satelli 1*, Jiemiao Hu 1*, Xueqing Xia 1, Shulin Li 1,2 . 1. Department of Pediatrics, The University of Texas MD Anderson Cancer Center, Houston, Texas; 2. The University of Texas Graduate School of Biomedical Sciences, Houston, Texas. This discovery highlights that pyruvate as a common metabolite can regulate signaling pathways in cell-fate determination. Elevated Exogenous Pyruvate Potentiates Mesodermal Differentiation through Metabolic Modulation and AMPK/mTOR Pathway in Human Embryonic Stem Cells: Stem Cell Reports T Cell Co-Signaling Pathway: Ligand-Receptor Interactions. Click on one of the subfamilies of IgSF or TNFRSF co-signaling receptors shown in the Explore Pathways box below to see how the different members of each family affect T cell activation.