Cells differentiate into lymphocytes

May 14, 2012 · Adoptive cell transfer (ACT) of antigen-specific CD8 + cytotoxic T lymphocytes (CTLs) is a promising treatment for a variety of malignancies 1 . CTLs can recognize malignant cells by interacting tumor antigens with the T cell receptors (TCR), and release cytotoxins as well as cytokines to kill malignant cells.

Most B-lymphocytes differentiate into antibody-secreting plasma cells. T-lymphocytes (T-cells) are responsible for cell-mediated immunity, the production of cytotoxic T-lymphocytes (CTLs), activated macrophages, activated NK cells, and cytokines against a specific antigen. T4-lymphocytes have CD4 molecules and T-cell receptors on their surface for antigen recognition.

Most B-lymphocytes differentiate into antibody-secreting plasma cells. T-lymphocytes (T-cells) are responsible for cell-mediated immunity, the production of cytotoxic T-lymphocytes (CTLs), activated macrophages, activated NK cells, and cytokines against a specific antigen. T4-lymphocytes have CD4 molecules and T-cell receptors on their surface for antigen recognition. A memory cell is an antigen-specific B or T lymphocyte that does not differentiate into effector cells during the primary immune response, but that can immediately become effector cells upon re-exposure to the same pathogen. During the primary immune response, memory cells do not respond to antigens and do not contribute to host defenses. A memory cell is an antigen-specific B or T lymphocyte that does not differentiate into effector cells during the primary immune response, but that can immediately become effector cells upon re-exposure to the same pathogen. During the primary immune response, memory cells do not respond to antigens and do not contribute to host defenses. Th2 cells secrete IL-4 and IL-10 (and other cytokines) and help antigen-primed B lymphocytes differentiate into plasma cells and secrete antibodies, the effector molecules of humoral responses. T cells, Treg cells, with the phenotype CD4+CD25+, express the signature transcription factor FOXP3 and usually secrete IL-10 and transforming growth ... B cells with high-affinity antigen receptors exit the GC and differentiate into either memory B cells, which express a similar transcriptional signature to mature B cells, or long-lived plasma cells, which express high levels of BLIMP1, IRF4 and XBP1 and produce large quantities of antibody. A memory cell is an antigen-specific B or T lymphocyte that does not differentiate into effector cells during the primary immune response, but that can immediately become effector cells upon re-exposure to the same pathogen. During the primary immune response, memory cells do not respond to antigens and do not contribute to host defenses.

Lymphocytes differentiate in primary lymphoid organs where they commit a lymphocytic lineage, express B or T cell receptors (BCR and TCR, resp.,), which are essential for cell survival and further maturation as well as function, and are selected according to their capacity of antigen recognition. Th2 cells secrete IL-4 and IL-10 (and other cytokines) and help antigen-primed B lymphocytes differentiate into plasma cells and secrete antibodies, the effector molecules of humoral responses. T cells, Treg cells, with the phenotype CD4+CD25+, express the signature transcription factor FOXP3 and usually secrete IL-10 and transforming growth ... Generation of T Cells. T cell development occurs in the thymus; the thymic microenvironment directs differentiation as well as positive and negative selection. Lymphoid progenitors which have developed from hematopoietic stem cells in the bone marrow migrate to the thymus to complete their antigen-independent maturation into functional T cells .